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The serum is a highly concentrated water or oil-based product. When using concentrates, besides getting a quick cosmetic effect, it also gives psychological satisfaction. This is because the effect can be seen immediately. The serum has a rapid absorption property and has the ability to penetrate into the deeper layers of the skin due to its non-greasy finish and intensive formula with a very high concentration of active substances. However, not all humans can use cosmetic serum for their skin. Some types of cosmetic serum can cause allergic reactions to the skin. Considering these parameters, we aimed to formulate a moisturizing serum for the skin using beetroot and mangosteen peels. The objective was to make Beetglowcinia serum. Both these peels are known for their bioactive properties. This serum has a super-special blend of natural active ingredients to penetrate the skin’s epidermis and cells, resulting in a brighter and clearer complexion. It has skin smoothing ingredients to improve skin texture and leaves skin softer, fairer and smoother. Various physical, chemical and biological evaluations were done on this product. The formulation was found to have good spreadability and is free from heavy metals. A skin irritation study proved that this formulation was non-sensitive and can be used by individuals with any skin type. It is intended to provide moisturizing and brightening action within a week of usage without affecting the skin. This innovation was designed to deliver an excellent solution by creating a natural serum which leads to healthy and moisturizing skin naturally. Indeed, this triggers our interest as there are huge needs and people are changing towards healthier lifestyle.